Kazuharu Kamachi Selected Research

OR-2100

1/2022

Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia.

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Kazuharu Kamachi Research Topics

Disease

5	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2022 - 01/2018
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 12/2020
3	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020 - 01/2018
2	Neoplasms (Cancer) 01/2022 - 01/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021
1	BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative) 06/2020
1	Rheumatoid Arthritis 06/2020
1	Crohn Disease (Crohn's Disease) 01/2020
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 02/2019
1	Plasmacytoma 03/2018
1	Exanthema (Rash) 01/2018

Drug/Important Bio-Agent (IBA)

3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2020
3	Tyrosine Kinase InhibitorsIBA 01/2022 - 12/2020
3	mogamulizumabIBA 02/2019 - 01/2018
1	OR-2100IBA 01/2022
1	pyrimidineIBA 01/2022
1	Imatinib Mesylate (Gleevec)FDA Link 01/2022
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022
1	EnzymesIBA 01/2022
1	MethyltransferasesIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 12/2020
1	SteroidsIBA 06/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	Monoclonal AntibodiesIBA 01/2019
1	CC ChemokinesIBA 01/2019
1	Bortezomib (Velcade)FDA Link 03/2018
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2018

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2020
1	Transplantation 01/2022
1	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 01/2022
1	Induction Chemotherapy 06/2020
1	Stem Cell Transplantation 01/2020
1	Drug Therapy (Chemotherapy) 02/2019
1	Hematopoietic Stem Cell Transplantation 03/2018